- 姓名： 李颖
- 性别： 男
- 职称： 研究员
- 职务：
- 学历： 博士
- 电话：
- 传真：
- 电子邮件： "liying@wipm.ac.cn； liyingbiochip@gmail.com"
- 所属部门： 生物磁共振波谱研究部
- 通讯地址： 湖北省武汉市武昌区小洪山西30号
李颖，博士、博士生导师，入选中科院引才计划、湖北省引才计划、湖北省杰青；于2008年和2013年分别获得华中科技大学生物医学工程的学士和博士学位；2013-2017年在美国休斯敦卫理公会医院（康奈尔大学威尔医学院附属医院）进行博士后研究；2017-2018年在美国杜克大学机械工程与材料学院任Research Scientist；2018年9月加入中科院精密测量科学与技术创新研究院（原武汉物理与数学研究所）。李博士从事微流控生物芯片研究十余年，专注于转化医学和精准医疗等相关研究，在Nature Communications, JACS，ACS Nano，Science Advances, Analytical Chemistry, Biosensors and Bioelectronics等期刊上已发表SCI论文40余篇，其中第一作者/通讯作者论文20余篇，h-index>20，授权中国发明专利10余项（6项作为第一发明人）、美国专利2项，申请PCT一项，出版书籍章节2节；现为Military Medical Research、Exploration等期刊青年编委。
简 历：
Military Medical Research、Exploration、Cancer Biology & Medicine青年编委；多次受邀为Analytical Chemistry，Lab Chip, Advanced Healthcare Materials, Applied Materials and Interfaces, Talanta等期刊审稿。
社会任职：
- 微芯片与核磁共振技术联用；微纳器件设计与应用；转化医学
研究方向：
1. 湖北省杰出青年项目，2023；
2. 国家重点研发计划课题负责人，2022；
3. 国家自然科学基金面上项目，2021；
4. 湖北省高价值知识产权培育工程，2021；
5. 武汉市“黄鹤英才”计划，2020
6. 武汉市“朝阳计划”，2020
7. 横向项目，基于微流控芯片的核酸检测新方法，2020
8. 中科院引才计划，择优通过，2020
9. 湖北省引才计划，2019
10.国家自然科学基金青年项目，2019
承担科研项目情况：
重要论文（第一或通讯作者）
1. Zhichen Xu#, Dongjuan Chenc#, Tao Li, Jiayu Yan, Jiang Zhu, Ting He, Rui Hu, Ying Li*, Yunhuang Yang, Maili Liu, Microfluidic space coding for multiplexed nucleic acid detection via CRISPR-Cas12a and recombinase polymerase amplification, Nature Communications, 2022, 13, 6480. (IF=16.6)
2. Biao Wang#, Bang？Shun He#, *, Xiao？Lan Ruan, Jiang Zhu, Rui Hu, Jie Wang, Ying Li*, Yun？Huang Yang, Maili Liu, An integrated microfluidics platform with high？throughput single？cell cloning array and concentration gradient generator for efficient cancer drug effect screening, Military Medical Research, 2022, 9, 51. (IF=21.1)
3. Hu Zhou, Zhichen Xu, Liang He, Zhijie Wang, Tao Zhang, Ting Hu, Fanwei Huang, Dongjuan Chen, Ying Li*, Yunhuang Yang, Xiaoyuan Huang*, Coupling CRISPR/Cas12a and Recombinase Polymerase Amplification on a Stand-Alone Microfluidics Platform for Fast and Parallel Nucleic Acid Detection, Analytical Chemistry, 2023, 95, 3379-3389. (IF=7.4)
4. Yin Zhao, Dongjuan Chen, Zhichen Xu, Tao Li, Jiang Zhu, Rui Hu, Guoyong Xu*, Ying Li*, Yunhuang Yang*, Maili Liu, Integrating CRISPR-Cas12a into a Microfluidic Dual-Droplet Device Enables Simultaneous Detection of HPV16 and HPV18, Analytical Chemistry, 2023, 95, 3476-3485. (IF=7.4)
5. Zheyu Li, Qingjia Bao, Chaoyang Liu, Ying Li*, Yunhuang Yang*, Maili Liu, Recent advances in microfluidics-based bioNMR analysis, Lab on a Chip, 2023, 23, 1213-1225. (IF=6.1)
6. Zheyu Li, Yue Xiong, Shuangli Li, Jiang Zhu, Rui Hu*, Ying Li*, Yunhuang Yang, Maili Liu, A fast microfluidic mixer enabling rapid preparation of homogeneous PEG and bicelle media for RDC in NMR analysis, Chemical Engineering Journal, 2022, 431, 133817. (IF=15.1)
7. Tao Li#, Rui Hu#, Jianbo Xia#, Zhichen Xu, Dongjuan Chen, Jingou Xi, Bi-Feng Liu, Jiang Zhu, Ying Li*, Yunhuang Yang and Maili Liu*, G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection, Biosensors and Bioelectronics, 2021, 187, 113292. (IF=12.6)
8. Rui Hu, Ying Li*, Yunhuang Yang* and Maili Liu, Mass Spectrometry-based Strategies for Single-cell Metabolomics, Mass Spectrometry Review, 2023, 42, 67–94. (IF=6.6)
9. Ying Li*，#, Tao Li，#, Bi-Feng Liu, Rui Hu, Jiang Zhu, Ting He, Xin Zhou, Conggang Li, Yunhuang Yang and Maili Liu*, CRISPR-Cas12a trans-cleaves DNA G-quadruplexes, Chemical Communications, 2020, 56, 12526. (IF=4.9)
10. Ying Li*, Pengchao Zhang, Tao Li, Rui Hu, JiangZhu, Ting He, Yunhuang Yang, Maili Liu, A Virtual-Droplet System for Sensing MMP9 Activity of Single Suspended and Adhered Cancer Cells, Sensors and Actuators B: Chemical, 2020, 308, 12449. (IF=8.4)
11. Ying Li*, Jeffrey D. Motschman, Sean T. Kelly, Benjamin B. Yellen*, Injection Molded Microfluidics for Establishing High-Density Single Cell Arrays in an Open Hydrogel Format, Analytical Chemistry, 2020, 92, 3, 2794-2801. (IF=7.4)
12. Rui Hu, Chao Liu, Jie Xuan, Youzhi Xu, Tao Li, Bi-Feng Liu, Ying Li*, Yunhuang Yang, 3D Hydrodynamic Flow Focusing-based Micromixer Enables High-Resolution Imaging for Studying the Early Folding Kinetics of G-Quadruplex, Sensors and Actuators B: Chemical, 2019, 293, 312-320. (IF=8.4)
13. Ying Li, Jie Xuan, Yujun Song, Wenjin Qi, Bangshun He, Ping Wang*, Lidong Qin*, Nanoporous Glass Integrated in Volumetric Bar-Chart Chip for Point-of-Care Diagnostics of Non-Small Cell Lung Cancer. ACS Nano, 2016, 10 (1), 1640-1647. (IF=17.1)
14. Ying Li, Uvaraj Uddayasankar, Bangshun He, Ping Wang*, Lidong Qin*, Fast, Sensitive and Quantitative Point-of-Care Platform for the Assessment of Drugs of Abuse in Urine, Serum and Whole Blood. Analytical Chemistry, 2017, 89 (16), 8273–8281. (IF=7.4)
15. Ying Li, Jie Xuan, Yujun Song, Ping Wang*, Lidong Qin*, A Microfluidic Platform with Digital Readout and Ultra-Low Detection Limit for Quantitative Point-of-Care Diagnostics. Lab on a Chip, 2015, 15 (16), 3300-3306. (IF=6.1)
16. Ying Li, Jie Xuan, Tom Xia, Xin Han, Yujun Song, Zheng Cao, Xin Jiang, Yi Guo, Ping Wang*, and Lidong Qin*, Competitive Volumetric Bar-Chart Chip with Real-Time Internal Control for Point-of-Care Diagnostics, Analytical Chemistry, 2015, 87 (7), 3771–3777. (IF=7.4)
17. Ying Li, Chao Liu, Xiaojun Feng, Youzhi Xu, Bi-Feng Liu*, An Ultra-fast Microfluidic Mixer for Tracking the Early Folding Kinetics of Human Telomere G-quadruplex, Analytical Chemistry, 2014, 86(9), 4333-4339. (IF=7.4)
18. Ying Li, Youzhi Xu, Xiaojun Feng, Bi-Feng Liu*, A Rapid Microfluidic Mixer for High Viscosity Fluids to Track Ultrafast Early Folding Kinetics of G-quadruplex under Molecular Crowding Conditions, Analytical Chemistry, 2012, 84(21), 9025-9032. (IF=7.4)
代表论著：
专利申请：
1. 精密测量院突出成果奖，2021
2. 精密测量创新研究院“青年突击手”， 2021
3. 创业武汉星光大道总决赛优胜奖，2019
4. 湖北省第二届“工友杯” 大赛中央在鄂和省属企业赛区，第二名，2019
5. 创业武汉星光大道中小企业融通专场第一名，2019
人才队伍